Share to

Details

Safety

Technical Documents

Articles

reviews

Consult

returns

Product details

名称

SNT-207858 free base

别名

SNT-207858 游离碱

英文名称

SNT-207858 free base

货号

S655021-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 ( MC-4 ) receptor antagonist. SNT207858 free base has an IC 50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor In Vitro SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mice with C26 adenocarcinoma-induced cachexia model Dosage: 30 mg/kg Administration: Oral administration; once daily; 15 days Result: Significantly reduced the tumor induced weight loss. IC50& Target:MC-4 receptor

生化机理

SNT207858 游离碱是一种具有选择性、血脑屏障穿透性、强效和口服活性的黑色素皮质素-4（MC-4）受体拮抗剂。SNT207858 free base 对 MC-4 受体的 IC 50 值为 22 nM（结合）和 11 nM（功能）。

CAS号

1104662-66-9(DMSO)

分子式

C32H43Cl2N5O3

分子量

616.62 g/mol

Smiles

CCC(COC1=C(N=CC=C1)C2CCN(CC2)C(=O)C(CC3=C(C=C(C=C3)Cl)Cl)NC(=O)N4CCCC4)N5CCCC5

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！