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名称

SIRT-IN-3

英文名称

SIRT-IN-3

货号

S655046-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

避光,-80℃储存

运输条件

超低温冰袋运输

产品介绍

SIRT-IN-3 is a potent SIRT inhibitor, with an IC 50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3 , respectively (IC 50 of 74 μM and 235 μM for SIRT2 and SIRT3 , respectively). In Vitro SIRT-IN-3 (Compound 7) (30-300 μM; 8 hours) causes p53 acetylation in in HCT116 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

生化机理

SIRT-IN-3 是一种强效的 SIRT 抑制剂，对 SIRT1 的 IC 50 为 17 μM。SIRT-IN-3 对 SIRT1 的选择性分别是 SIRT2 和 SIRT3 的 4 倍和 14 倍（对 SIRT2 和 SIRT3 的 IC 50 分别为 74 μM 和 235 μM）。

CAS号

1211-19-4(DMSO)

分子式

C13H12N2O

分子量

212.25 g/mol

Smiles

C1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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