SSTC3

SSTC3

S655350-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

SSTC3 is a casein kinase 1α (CK1α) activator ( K d = 32 nM) that inhibits WNT signaling ( EC 50 = 30 nM). SSTC3 exhibits minimal gastrointestinal toxicity compared to other classes of WNT inhibitors. In Vitro SSTC3 (0-1μM, 5 days) decreases the viability of HCT116 cells in an on-target manner. This capacity is significantly reduced when the mutant CTNNB1 allele driving its carcinogenic properties is deleted. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Colorectal cancer (CRC) cell lines. Concentration: 0-1 μM. Incubation Time: 5 days. Result: Decreased the viability. Western Blot AnalysisCell Line: SW403 cells. Concentration: 100 nM. Incubation Time: 15 min. Result: Increased β-catenin phosphate levels. In Vivo SSTC3 can be maintained for 24 hours after treatment . SSTC3 (25 mg/kg, ip once daily for 8-12 days) suppresses the growth of colorectal carcinoma in CD-1 mice . SSTC3 (10 mg/kg, ip once daily for 1 month) inhibits the growth of Apc mutation-driven tumors . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Five-week-old Apc min mice . Dosage: 10 mg/kg. Administration: IP for 1 month. Result: Inhibited the growth of Apc mutation-driven tumors. Animal Model: CD-1 mice. Dosage: 25 mg/kg. Administration: IP once daily for 8-12 days. Result: Inhibited the growth of HCT116 xenografts. Attenuated the growth of this metastatic CRC PDX and markedly reduced the cell density of residual cancer. Reduced the expression of WNT biomarkers in this CRC PDX.

SSTC3 是一种酪蛋白激酶 1α (CK1α) 激活剂（K d = 32 nM），可抑制 WNT 信号转导（EC 50 = 30 nM）。与其他类别的 WNT 抑制剂相比，SSTC3 的胃肠道毒性极小。

1242422-09-8(DMSO)

C23H17F3N4O3S2

518.53 g/mol

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