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8-姜烯酚是生姜中的一种刺激性酚类化合物，具有抗血小板 (IC50=5 μM)、抗癌和抗炎活性。8-姜烯酚抑制 COX-2 (IC50=17.5 μM)，可诱导人白血病细胞凋亡。8-姜烯酚选择性靶向 TAK1 和 TAK1-TAB1 (IC50=5 μM)，抑制 IKK、Akt 和 MAPK 信号通路，从而逆转发炎滑膜和类风湿性关节炎（RA）。 [8]-Shogaol, a kind of stimulating compound in ginger, has antiplatelet (IC50=5 μM), anti-cancer and anti-inflammatory activity. [8]-Shogaol inhibited COX-2 (IC50=17.5 μM), which led to the decline of human leukemia cells. 8-Shogaol Selective direction TAK1 sum TAK1-TAB1 (IC50=5 μM), suppress IKK, Akt sum MAPK signal pathway, and reverse synovitis synovial sum Air dampness (RA).

Specs ⸢ View details ⸥

Chinese name

8-姜烯酚

English name

[8]-Shogaol

Chinese alias

English alias

CAS number

36700-45-5

molecular formula

C19H28O3

molecular weight

304.42 g/mol

Exact mass

PSA

46.500 Å²

Logp

4.800

Technical Documents

36700-45-5 | 8-Shogaol.pdf
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