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Product details

名称

SBI-425

分子类型

小分子

英文名称

SBI-425

货号

S656179-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

SBI-425 is an orally active and potent TNAP ( tissue-nonspecific alkaline phosphatase ) inhibitor ( IC 50 =16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival In Vitro SBI-425 treatment suppresses Foxp3 expression in CD4 + and CD8 + T cells in splenocytes from CLP-injured mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo 1.19 Mouse PK parameters for SBI-425 Compds SBI-425 Cl p (mL/min/kg) 5.14 Vd (L/kg) 1.03 C max (μg/mL) 178 AUC (μg*hr/mL) 848 t 1/2 (hr) 2.3 %F 58 MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 16 nM (TNAP)

生化机理

SBI-425 是一种口服活性强效 TNAP（组织非特异性碱性磷酸酶）抑制剂（IC 50 =16 nM）。SBI-425 可抑制血管中的 TNAP，改善心血管参数和存活率。

CAS号

1451272-71-1(DMSO)

分子式

C13H12ClN3O4S

分子量

341.77 g/mol

Smiles

COC1=C(C=C(C=C1)Cl)S(=O)(=O)NC2=CN=CC(=C2)C(=O)N

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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