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Product details

名称

SGC-iMLLT

分子类型

未知

别名

同步加速器

英文名称

SGC-iMLLT

货号

S656347-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

SGC-iMLLT is a first-in-class chemical probe and a potent, selective inhibitor of MLLT1/3-histone interactions with an IC 50 of 0.26 μM. SGC-iMLLT shows high binding activity towards MLLT1 YEATS domain (YD) and MLLT3 YD (AF9/YEATS3) with K d s of 0.129 and 0.077 μM, respectively In Vivo SGC-iMLLT shows moderate metabolic resistance with t 1/2 of 53 min and 48 % remaining after 60 min, and the primary process for metabolism is N demethylation . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 0.26 μM (MLLT1 YD), Kd: 0.077 μM (MLLT3 YD), 0.129 μM (MLLT1 YD)

生化机理

SGC-iMLLT 是一种首创的化学探针，也是 MLLT1/3 组蛋白相互作用的强效选择性抑制剂，其 IC 50 为 0.26 μM。SGC-iMLLT 对 MLLT1 YEATS 结构域（YD）和 MLLT3 YD（AF9/YEATS3）具有很高的结合活性，其 K d s 为 0.129 an (0.129μM)。

CAS号

2255338-25-9(DMSO)

分子式

C22H24N6O

分子量

388.47 g/mol

Smiles

CC1CCCN1CC2=NC3=C(N2)C=C(C=C3)NC(=O)C4=CC5=C(C=C4)N(N=C5)C

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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