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名称

SIRT-IN-2

分子类型

小分子

英文名称

SIRT-IN-2

货号

S656554-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

SIRT-IN-2 is a potent inhibitor of SIRT1/2/3 , with IC 50 s of 4, 4, 7 μM, respectively. In Vitro SIRT-IN-2 (compound 31) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC 50 values are 4, 4, 7 μM, respectively. SIRT-IN-2 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 Å), occupying the nicotinamide C-pocket and acetyl lysine substrate channel. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:SIRT1 4 μM (IC 50 ) SIRT2 1 μM (IC 50 ) SIRT3 7 μM (IC 50 )

生化机理

SIRT-IN-2 是 SIRT1/2/3 的强效抑制剂，其 IC 50 s 分别为 4、4 和 7 μM。

CAS号

1431411-66-3(DMSO)

分子式

C15H21N5O3S2

分子量

383.49 g/mol

Smiles

CS(=O)(=O)NCCC1CCN(CC1)C2=NC=NC3=C2SC(=C3)C(=O)N

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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