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名称

STAT3-IN-12

英文名称

STAT3-IN-12

货号

S658739-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

STAT3-IN-12 is a potent STAT3 signal inhibitor that can inhibit IL-6 induced JAK/STAT3 signalling pathway activation. STAT3-IN-12 inhibits cancer cell growth, migration, and induce cell apoptosis as well as cycle arrest. STAT3-IN-12 can be used in cancer- Appearance:Solid IC50& Target:STAT3 In Vitro:STAT3-IN-12 (compound 24, 0-10 μM approximately, 72 h) inhibits cancer cell growth and migration in HepG2 and EC109 cells. STAT3-IN-12 (0-20 μM, 16 h) binds to the STAT3 protein and inhibits IL-6-mediated STAT3 phosphorylation, also inhibts STAT3 nuc In Vivo:STAT3-IN-12 (compound 24, intraperitoneal injection, 20, 40mg/kg, daily for 24 days) displays obvious antitumor activity in a mouse HepG2 cell xenograft tumor model without no obvious toxicity. MCE has not independently confirmed the accuracy of the Biological Activity:STAT3-IN-12 is a potent STAT3 signal inhibitor that can inhibit IL-6 induced JAK/STAT3 signalling pathway activation. STAT3-IN-12 inhibits cancer cell growth, migration, and induce cell apoptosis as well as cycle arrest. STAT3-IN-12 can be used in cancer-

分子式

C28H30N4O2

分子量

454.56 g/mol

Smiles

CCCN1C2=C(C=C3C(N(CCC)C(C4=CC=CC(OC)=C4)=N3)=C2)N=C1C5=CC=CC(OC)=C5

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「No Dangerous Attributes」

「No upstream and downstream information yet」

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