Share to

Details

Safety

Technical Documents

Articles

reviews

Consult

returns

Product details

名称

(S)-V-0219 hydrochloride

别名

(S)-V-0219 盐酸盐

英文名称

(S)-V-0219 hydrochloride

货号

S659084-5mg

包装规格

5mg

浓度

≥99%

储存温度

2-8°C储存,干燥

运输条件

冰袋运输

产品介绍

(S)-V-0219 hydrochloride is an enantiomer of V-0219 ( HY-143312 ). V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor -1 ( GLP-1R ). (S)-V-0219 hydrochloride activates calcium fluxes in HEK cells stably expressing hGLP- Appearance:Solid IC50& Target:GLP-1R In Vitro:(S)-V-0219 ((S)-9) (0.1 nM) hydrochloride potentiates calcium fluxes in HEK cells stably expressing hGLP-1R. (S)-V-0219 (0.1 nM) hydrochloride potentiates insulin secretion stimulated by GLP-1 in the stable human pancreatic cell line EndoC-βH1 under In Vivo:(S)-V-0219 ((S)-9) (0.04-0.2mg/kg; i.p.) hydrochloride improves glucose handling after injection of 2 g/kg glucose in normal male Wistar rats. (S)-V-0219 (0. 4mg/kg; i.g.) hydrochloride is orally active in fatty diabetic Zucker rats. (S)-V-021 Biological Activity:(S)-V-0219 hydrochloride is an enantiomer of V-0219 ( HY-143312 ). V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor -1 ( GLP-1R ). (S)-V-0219 hydrochloride activates calcium fluxes in HEK cells stably expressing hGLP-

分子式

C20H26ClF3N4O2

分子量

446.89 g/mol

Smiles

FC(C1=CC=C(C2=NOC(CN3C[C@H](CN4CCOCC4)CCC3)=N2)C=C1)(F)F.[H]Cl

溶解性

DMSO : 100 mg/mL (223.77 mM; ultrasonic and warming and heat to 60°C)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！