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Product details

名称

Spadin TFA

英文名称

Spadin TFA

货号

S659299-5mg

包装规格

5mg

浓度

≥99%

储存温度

避光,干燥,-80℃储存

运输条件

超低温冰袋运输

产品介绍

Spadin TFA, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with an IC 50 value of 10 nM. Spadin TFA enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and Appearance:Solid In Vitro:Spadin TFA (100 nM; COS-7 cells) has inhibitory effect of spadin on the TREK-1 channel and blocks 63% of the TREK-1 current stimulated by arachidonic acid. Spadin TFA (100 nM) blocks the TREK-1 channels activity in CA3 hippocampal neurons on brain sl In Vivo:Spadin TFA (10 μM, 100 μL; i.p.; for 30 min; male C57Bl/6J and TREK-1 deficient mice) increases of the 5-HT neuron firing rate in the dorsal raphe nucleus (DRN). Spadin TFA (0.01-100 μM, 100 μL; ICV, i.p. and i.v.; daily, for 7 days; male C57Bl/6J an Biological Activity:Spadin TFA, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with an IC 50 value of 10 nM. Spadin TFA enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and

分子式

C92H143F3N26O24

分子量

2126.36 g/mol

溶解性

DMSO : 100 mg/mL (47.03 mM; Need ultrasonic) H2O : 25 mg/mL (11.76 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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