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Product details

名称

SJF620 hydrochloride

别名

SJF620盐酸盐

英文名称

SJF620 hydrochloride

货号

S659469-5mg

包装规格

5mg

储存温度

避光,-20°C储存,充氩

运输条件

超低温冰袋运输

产品介绍

SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC 50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN. Appearance:Solid IC50& Target:Cereblon In Vitro:SJF620 hydrochloride is a PROTAC that retains potent degradation of BTK in cellular assays with a DC 50 of 7.9 nM in Burkitt lymphoma cell line NAMALWA. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo:SJF620 hydrochloride has a super pharmacokinetic profile in mice (1mg/kg; i.v.) with the half life (t 1/2 ) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802. MCE has not independently confirmed the accuracy of the Biological Activity:SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC 50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN.

分子式

C41H45ClN8O7

分子量

797.3 g/mol

Smiles

O=C(N1)C(CCC1=O)N(C2=O)CC3=C2C=CC(OCCOCCOCCN4CCC(CC4)N5N=C(C6=C(N)N=CN=C65)C7=CC=C(C=C7)OC8=CC=CC=C8)=C3.[H]Cl

酪氨酸激酶

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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