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Product introduction
多巴是一种在苯环的3和4位带有羟基取代基的羟基苯丙氨酸。它具有人体代谢物的作用。它是一种羟基苯丙氨酸、酪氨酸衍生物和非蛋白质源α-氨基酸。
Chinese name
3-(3,4-二羟苯基)-DL-丙氨酸
English name
2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
Chinese alias
3-(3,4-二羟基苯基)-DL丙氨酸 | DL-3-羟基酪氨酸
English alias
DL-DOPA | dl-beta-(3,4-Dihydroxyphenyl)-alpha-alanine | IM3 | Tyrosine, 3-hydroxy- | 3,4-Dihydroxyphenylalanine # | AKOS016843592 | SY343921 | alpha-amino-3,4-dihydroxy-Benzenepropanoic acid | DL-b-(3,4-Dihydroxyphenyl)alanine | H11952 | NSC118368 | NSC-1
CAS number
63-84-3
molecular formula
C9H11NO4
molecular weight
197.19
Exact mass
10mM in DMSO
PSA
104
Logp
-2.7
Safety
  • Treatment: 通常需要透析来缓解尿毒症的症状,直到肾功能恢复正常。
  • Hazard summary: 皮肤和强眼刺激物;[Sigma-Aldrich MSDS] 见左旋多巴。
  • exposure pathway: 内源性,摄入,皮肤接触(接触)
  • Toxicity summary: 尿毒症毒素如二羟基苯丙氨酸通过有机离子转运体(特别是OAT3)主动转运到肾脏。尿毒症毒素水平的增加可以刺激活性氧的产生。这似乎是通过尿毒症毒素直接结合或抑制NADPH氧化酶(特别是肾脏和心脏中丰富的NOX4)来介导的(A7868)。活性氧可以诱导几种不同的DNA甲基转移酶(DNMTs),这些酶参与一种称为KLOTHO的蛋白质的沉默。KLOTHO已被确定为在抗衰老、矿物质代谢和维生素D代谢中具有重要作用。多项研究表明,在急性和慢性肾脏疾病中,KLOTHO mRNA和蛋白质水平会降低...
  • Regulatory information: 澳大利亚工业化学品清单:化学品:DL-酪氨酸,3-羟基-
  • Toxicity Data: LD50: 2363 mg/kg (口服,小鼠) (A308) LD50: 609 mg/kg (口服,兔) (A308) LD50: 1780 mg/kg (口服,大鼠) (A308)
  • Health Effects: 长期接触尿毒症毒素可导致多种疾病,包括肾损伤、慢性肾脏病和心血管疾病。
  • Symptoms and Signs: 作为一种尿毒症毒素,这种化合物可引起尿毒症综合征。尿毒症综合征可能影响身体的任何部位,可导致恶心、呕吐、食欲不振和体重减轻。它还可引起精神状态改变,如意识混乱、意识降低、烦躁不安、精神病、癫痫和昏迷。也可能出现异常出血,如自发性出血或轻微损伤后大量出血。尿毒症综合征患者可能出现心脏问题,如心律不齐、心脏周围囊膜炎症(心包炎)和心脏压力增加。由于肺部和胸壁之间的积液(胸腔积液)导致的呼吸困难也可能出现。
  • Hazard categories and classifications: STOT SE 3 (89.6%)
  • Carcinogen Classification: 对人类无致癌性迹象(未被IARC列出)。
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Research chemical CAS 63-84-3 98% 1g

Yuanye Research chemical CAS 63-84-3 98% 1g, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

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