转肽酶 A,金黄色葡萄球菌，His-tag

S755808-50μg

50μg

重组

Staphylococcus aureus, N-terminal His-Tag

本产品适用于蛋白质和多肽的体外连接。研究表明转肽酶A可以产生环化蛋白质[1], 并可将多肽与多种取代基偶联，包括聚合物[2]、脂质[3]、荧光团[4]、糖[5]、 微球 [3]、肽核酸 [6]和其它基团。应用： 我们全面的上游工艺化学品系列不仅为生物制药生产商提供生产传统和创新治疗药物所需的优质原料，而且帮助他们更快地将产品投放市场并简化监管问题。请相信我们能够为您带来透明的供应链和可靠的全球采购能力，以最佳的法规支持和服务简化您的产品认证。 Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service. Application: This product is suitable for in vitro ligation of proteins and peptides to other. Sortase A has been shown to create circularized proteins [1] , as well as couple polypeptides to a wide range of substituents including polymers [2] , lipids [3] , fluorophores [4] , sugars [5] , microspheres [3] , peptide nucleic acids [6] , among others.

葡萄球菌转肽酶 A 是一种细菌转肽酶，它通过在 LPXTG 识别基序的苏氨酸和甘氨酸之间切割，将蛋白质共价连接到细菌细胞壁，并催化苏氨酸的羧基和细胞壁肽聚糖的氨基之间形成酰胺键 [7] 这种化学特性可用于将具有 C 端 LPETGX 基序的蛋白质/肽与其它具有甘氨酸或氨基亚甲基基序的蛋白质或分子进行位点特异性连接 [8] 。