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Product introduction

Lonafarnib (Sch66336) 是一种有效的法尼基蛋白转移酶 (FPTase) 抑制剂，作用于 H-ras，K-ras 和 N-ras，IC50 分别为 1.9 nM，5.2 nM 和 2.8 nM。Lonafarnib 具有抗肝炎三角洲病毒 (HDV) 的活性。 Lonafarnib (SCH66336) 是一种有效的法尼基蛋白转移酶 (FPTase) 抑制剂，作用于H-ras，K-ras-4B和N-ras，无细胞试验中IC50分别为1.9 nM， 5.2 nM和2.8 nM。Phase 3。 Lonafarnib（SCH66336、Sarasar）是不含肽键和巯基的三环化合物，是一种有效的、选择性的法尼基转移酶（FTase）抑制剂。该小分子化合物的分子式为C27H31Br2ClN4O2，分子量为638.82。法尼基化的Ras蛋白对驱动细胞增殖、生长和存活的信号转导通路具有调控作用，且对其膜定位也是不可或缺的。Lonafarnib可抑制ras蛋白翻译后的法尼基化反应，从而阻断RAS向质膜的易位。

Specs ⸢ View details ⸥

Chinese name

洛那法尼, 蛋白法尼基转移酶抑制剂

English name

Lonafarnib

Chinese alias

洛那法尼布 | 4- [2- [4-[(11R)-3,10-二溴-8-氯-6,11-二氢-5H苯并[5,6]环庚[1,2-b]吡啶-11-基] -1-哌啶基] -2-氧乙基] -1-哌啶甲酰胺

English alias

1-Piperidinecarboxamide, 4-(2-(4-((11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)- | 1-Piperidinecarboxamide, 4-(2-(4-((11R-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)p

CAS number

193275-84-2

molecular formula

C27H31Br2ClN4O2

molecular weight

638.82 g/mol

Exact mass

PSA

79.500 Å²

Logp

4.8

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Lonafarnib 10mM in DMSO 1ml

Name: Lonafarnib 10mM in DMSO 1ml
Brand: 麦克林
SKU: S793815-1ml

Lonafarnib 10mM in DMSO 1ml Macklin 193275-84-2, complete specifications, for production, research, laboratory testing and inspection, digital one-stop procurement platform for scientific materials.

item number：S793815-1ml

Product model：1ml

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Lead Time：30days

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Lonafarnib 10mM in DMSO 1ml

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