- Treatment： 通常需要透析来缓解尿毒症的症状，直到肾功能恢复正常。
- exposure pathway： 内源性，摄入，皮肤接触(接触)
- Toxicity summary： 尿素毒素如亚精胺通过有机离子转运体(特别是OAT3)主动转运到肾脏。尿素毒素水平升高可刺激活性氧的产生。这似乎是通过尿素毒素直接结合或抑制NADPH氧化酶(特别是肾脏和心脏中丰富的NOX4)酶来介导的(A7868)。活性氧可以诱导几种不同的DNA甲基转移酶(DNMTs)，这些酶参与一种称为KLOTHO的蛋白质的沉默。KLOTHO已被确定为在抗衰老、矿物质代谢和维生素D代谢中具有重要作用。多项研究表明，在急性或慢性肾脏疾病中，KLOTHO mRNA和蛋白质水平会升高...
- Regulatory information： 新西兰EPA化学品状态清单：亚精胺：没有单独批准，但可在适当的团体标准下使用
- Health Effects： 长期接触尿毒症毒素可导致多种疾病，包括肾损伤、慢性肾脏病和心血管疾病。
- Symptoms and Signs： 作为一种尿毒症毒素，这种化合物可引起尿毒症综合征。尿毒症综合征可能影响身体的任何部位，可导致恶心、呕吐、食欲不振和体重减轻。它还可引起精神状态改变，如意识混乱、意识降低、烦躁不安、精神病、癫痫和昏迷。也可能出现异常出血，如自发性出血或轻微损伤后大量出血。尿毒症综合征患者可能出现心脏问题，如心律不齐、心脏周围囊膜炎症（心包炎）和心脏压力增加。由于肺部和胸壁之间的积液（胸腔积液）导致的呼吸困难也可能出现。
- Hazard categories and classifications： 眼睛损伤 1 (81.9%)
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
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Research chemical CAS 124-20-9 1ml
Research chemical CAS 124-20-9 1ml, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.
