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Product introduction

SAR-405是一种选择性 PIK3C3/Vps34 抑制剂，IC50为1.2 nM，Kd 为1.5 nM，可防止自噬并与肿瘤细胞中的 MTOR 抑制协同作用。它抑制饥饿或 mTOR 抑制诱导的自噬，具有抗癌活性。 SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor (IC50:1.2 nM; Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells.

Specs ⸢ View details ⸥

Chinese name

SAR-405,PIK3C3/Vps34抑制剂, 磷脂酰肌醇 3-激酶催化亚基 3 型抑制剂

English name

SAR-405

Chinese alias

(S)-9-((5-氯吡啶-3-基)甲基)-2-((R)-3-甲基吗啉)-8-(三氟甲基)-6,7,8,9-四氢-4H-嘧啶并[1,2-a]嘧啶-4-酮

English alias

(S)-9-((5-Chloropyridin-3-yl)methyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one

CAS number

1523406-39-4

molecular formula

C19H21ClF3N5O2

molecular weight

443.85 g/mol

Exact mass

PSA

61.300 Å²

Logp

2.200

Technical Documents

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SAR405 10mM in DMSO 1ml

Name: SAR405 10mM in DMSO 1ml
Brand: 麦克林
SKU: S797446-1ml

SAR405 10mM in DMSO 1ml Macklin 1523406-39-4, complete specifications, for production, research, laboratory testing and inspection, digital one-stop procurement platform for scientific materials.

item number：S797446-1ml

Product model：1ml

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Lead Time：30days

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SAR405 10mM in DMSO 1ml

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