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Product introduction
MK-5108也叫VX-689,是一种新型有效选择性Aurora A激酶(AAK)抑制剂,通过竞争性结合AAK的ATP结合位点,有效抑制AAK活性,IC50值为0.064 nM。MK-5108对Aurora家族的其他激酶也有抑制作用,作用于Aurora B激酶的IC50值为14 nM,Aurora C激酶的IC50值为12 nM。MK-5108已被广泛研究,发现其对各种癌症包括乳腺癌、宫颈癌、结直肠癌、卵巢癌和胰腺癌均具有抗肿瘤活性。
Chinese name
MK-5108(VX-689),Aurora A抑制剂, 丝氨酸/苏氨酸蛋白激酶 Aurora-A 抑制剂
English name
MK-5108 (VX-689)
Chinese alias
-
English alias
HMS3656D06 | NCGC00024591-03 | BRD-K53665955-001-01-4 | GTPL8061 | MK 5108 | NSC800796 | NSC-800796 | MFCD22124479 | trans-4-(3-chloro-2-fluorophenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid | SW220174-1 | trans-4-(
CAS number
1010085-13-8
molecular formula
C22H21ClFN3O3S
molecular weight
461.94 g/mol
Exact mass
-
PSA
113.000 Ų
Logp
5.4
Technical Documents
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Research chemical CAS 1010085-13-8 ≥98% 25mg

Yuanye Research chemical CAS 1010085-13-8 ≥98% 25mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:S80018-25mg
Product model:25mg
level: ≥98% 25mg
Lead Time:30days
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