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Product introduction
Apitolisib (GDC-0980, RG7422, GNE 390)是一种有效的,I型PI3K抑制剂,作用于PI3Kα/β/δ/γ,无细胞试验中IC50分别为5 nM/27 nM/7 nM/14 nM,也是mTOR抑制剂,无细胞试验中Ki为17 nM,比作用于其他PIKK家族激酶选择性高。Apitolisib 在胰腺癌细胞中可同时激活自噬与凋亡。 Apitolisib (GDC-0980, RG7422) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM in cell-free assays, respectively. Also a mTOR inhibitor with Ki of 17 nM in a cell-free assay, and highly selective versus other PIKK family kinases. A PI3K and FRAP (mTOR) kinase inhibitor
Chinese name
GDC-0980 (RG7422), PI3 激酶 I 类抑制剂
English name
GDC-0980 (RG7422)
Chinese alias
-
English alias
1032754-93-0 | Apitolisib (USAN/INN) | APITOLISIB [USAN] | GDC-0980,CAS:1032754-93-0 | YOVVNQKCSKSHKT-HNNXBMFYSA-N | J-502360 | GDC-0980 (RG7422) | (S)-1-(4-((2-(2-AMINOPYRIMIDIN-5-YL)-7-METHYL-4-(MORPHOLIN-4-YL)THIENO(3,2-D)PYRIMIDIN-6-YL)METHYL)PIPERAZI
CAS number
1032754-93-0
molecular formula
C23H30N8O3S
molecular weight
498.61 g/mol
Exact mass
-
PSA
162.000 Ų
Logp
0.2
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MedMol Apitolisib 99% 10mg

MedMol Apitolisib 99% 10mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:S80040-10mg
Product model:10mg
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Lead Time:30days
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