WS6是促_beta_细胞增生的新型小分子，在啮齿类动物和人源原发性胰岛中EC50值为0.28uM。 Information WS6 is a β cell proliferation inducer via modulation ofErb3 binding protein-1 (EBP1)and theIκB kinasepathway. Targets EBP1 ; IκB kinase In vitro WS6 induces R7T1 cell proliferation with EC50 of 0.28 μM, and promotes β cell proliferation in rodent and human primary islets. Both Erb3 binding protein-1 and the IκB kinase pathway are confirmed to function in the mechanism of action of WS6. In vivo In RIP-DTA mouse model of β cell ablation, WS6 (50 mg/kg p.o.) ameliorates diabetes, and induces concomitant increases in β cell proliferation and β cell number. Cell Research(from reference) Cell lines：R7T1 cells Concentrations：~10 μM Incubation Time：4 days