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Product introduction

Optovin是一个可逆的光活化的TRPA1活化剂。 Optovin是TRPV1的活化剂. 瞬时受体电位阳离子通道亚家族A成员1(TRPA1)是一种离子通道,参与信号转导和生长控制.TRPA1信号在慢性炎症和神经性疼痛中起重要作用. Optovin是TRPA1的光激活剂.在分离的小鼠背根神经节(DRG)感觉神经元中,optovin显著激活33％(35/105) 的DRG神经元,但在黑暗中没有激活.在转染人TRPA1的HEK293T细胞中,optovin活化细胞.Optovin通过光活化中间体活化TRPA1通道,光活化中间体与该通道氧化还原敏感的半胱氨酸残基反应. 在野生型斑马鱼胚胎中,optovin增加光依赖的运动活性,EC50值为2 μM.Optovin诱导斑马鱼对387 nm光刺激的响应.Optovin作用于感觉神经元,对光依赖运动活动的增加不依赖于视觉通路.在含有trpa1b突变体的斑马鱼中,optovin没有作用,这表明optovin的活性必须有trpa1b的参与.在成年小鼠中,optovin诱导摇头行为. Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Specs ⸢ View details ⸥

Chinese name

Optovin(异构体混合物)

English name

Optovin (mixture of isomers)

Chinese alias

(5E)-5-[(2,5-二甲基-1-吡啶-3-基-吡咯-3-基)亚甲基]-2-亚磺酰基-1,3-噻唑烷-4-酮

English alias

CAS number

348575-88-2

molecular formula

C15H13N3OS2

molecular weight

315.41 g/mol

Exact mass

10mM in DMSO

PSA

104.000 Å²

Logp

2.9

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Research chemical 99% 10mg

Name: Research chemical 99% 10mg
Brand: MedMol
SKU: S80668-10mg

Research chemical 99% 10mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number：S80668-10mg

Product model：10mg

level： 99% 10mg

Lead Time：30days

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