- Treatment： 如果发生过量，也可能导致症状性低钙血症；此类患者应接受短期静脉钙治疗。(L1712)
- exposure pathway： 肠外（静脉注射）。静脉给药后血浆浓度迅速上升。
- Harmful effect： 有报告显示帕米膦酸盐可引起其他不良反应，如荨麻疹和非典型股骨骨折，但此类病例数量较少。
- Toxicity summary： 帕米膦酸的作用机制是抑制骨吸收。帕米膦酸吸附到骨中的磷酸钙（羟基磷灰石）晶体上，并可能直接阻断这种骨矿组分的溶解。体外研究也表明，抑制破骨细胞活性有助于抑制骨吸收。帕米膦酸还靶向法尼基焦磷酸(FPP)合成酶。含氮双膦酸盐（如帕米膦酸、阿仑膦酸盐、利塞膦酸盐、伊班膦酸盐和唑来膦酸盐）似乎作为异戊二烯二磷酸脂质的类似物，从而抑制甲羟戊酸途径中的FPP合成酶。抑制破骨细胞中的这种酶可阻止异戊二烯脂质（FPP和GGPP）的生物合成，这些脂质对于翻译后法尼...
- Health Effects： 已有少数葡萄膜炎、虹膜睫状体炎、巩膜炎和表层巩膜炎的病例报告，包括一例巩膜炎和一例在单独再激发后出现的葡萄膜炎病例。
- Symptoms and Signs： 副作用包括过敏反应、肾脏问题、癫痫发作、血液中钙、镁或磷水平低
- Hazard categories and classifications： 急性毒性 4 (100%)
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
- Drug Induced Liver Injury： 参考文献：DOI:10.1016/j.drudis.2019.09.022
- Effects During Pregnancy and Lactation： 截至修订日期，未找到相关已发表信息。
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MedMol Pamidronic Acid See P172500 98% 50mg
MedMol Pamidronic Acid See P172500 98% 50mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.
