- exposure pathway： 口服
- Toxicity summary： Tiratricol是T4(甲状腺素)的一种天然代谢产物，也是T3(三碘甲状腺原氨酸)的结构类似物。血浆中可检测到低浓度的tiratricol，但tiratricol在甲状腺生理中无已知作用。Tiratricol对T3受体具有高亲和力，在治疗剂量下可抑制促甲状腺激素(TSH)分泌，而不会引起显著的周围效应，如增加基础代谢率和心率。Tiratricol可能降低总胆固醇和LDL胆固醇，并刺激骨形成。口服剂量的约67%被吸收；半衰期为6小时。(L2139) 血清性激素结合球蛋白水平增加了55±13%，表明肝脏对tiratricol的反应增强。Tiratricol已对心血管系统产生影响...
- Health Effects： 口服(甲碘氨)三碘甲状腺原氨酸可引起严重腹泻、疲劳、嗜睡和显著体重减轻。可能发生心脏病发作和中风，以及甲状腺功能亢进的症状，包括食欲增加、腹部绞痛、震颤、月经不调、神经紧张、失眠、出汗、不耐热、发热、心悸、心动过速、脉搏和血压增加、胸痛和心律失常。病例报告表明(甲碘氨)三碘甲状腺原氨酸与中枢性甲状腺功能减退、假性甲状腺功能减退、核间眼肌麻痹和肝毒性有关。（L2139）它已被研究用于减少甲状腺肿。它还显示出一些减少使用皮质类固醇引起的萎缩的有效性。（维基百科）(甲碘氨)三碘甲状腺原氨酸已被用于抑制垂体TSH分泌，w...
- Hazard categories and classifications： 急性毒性4级（97.6%）
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
- Drug Induced Liver Injury： 参考文献：DOI:10.1016/j.drudis.2019.09.022
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Research chemical ≥98% 100mg
Research chemical ≥98% 100mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.
