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Product introduction
依匹斯汀是一种苯并氮䓬,是6,11-二氢-5H-二苯并[b,e]氮䓬,其中氮杂环与4,5-二氢-1H-咪唑-2-胺的e侧融合。它具有H1受体拮抗剂、组胺拮抗剂、抗过敏剂和眼科药物的作用。它是胍类和苯并氮䓬的成员。
Chinese name
epinastine, H 1 受体拮抗剂
English name
2,4-diazatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),3,7,9,11,14,16-heptaen-3-amine
Chinese alias
依匹斯汀
English alias
AMY33372 | Epinastinum | NCGC00165791-02 | R06AX24 | CHEBI:51032 | Epinastin | Epinastine (INN) | (+/-)-Epinastine | EX-A4762 | (+-)-Epinastine | 3-amino-9,13b-dihydro-1H-benz(c,f)imidazo(1,5a)azepine | EPINASTINE [WHO-DD] | NCGC00165791-03 | Q632405 | 1H
CAS number
80012-43-7
molecular formula
C16H15N3
molecular weight
249.31
Exact mass
-
PSA
41.6
Logp
3.5
Safety
  • Harmful effect: 依匹斯汀即使在动物模型的高剂量下也不会致畸。然而,来自人体临床试验的数据不足,因此,仅在益处大于潜在风险的情况下才应在孕期使用。
  • Toxicity summary: 迄今为止尚未报告依匹斯汀过量的病例。然而,在发生过量时,医疗机构和医疗保健提供者必须迅速行动以确保气道通畅且没有循环衰竭。
  • Regulatory information: REACH注册物质:状态:活跃 更新:2018-06-07 https://echa.europa.eu/registration-dossier/-/registered-dossier/25792
  • Hazard categories and classifications: 水生慢性2类 (50%)
  • Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
  • Effects During Pregnancy and Lactation: 注射给药的相对高剂量抗组胺药可降低非哺乳期妇女和产后早期妇女的基础血清催乳素。然而,产后母亲使用抗组胺药预处理不影响哺乳诱导的催乳素分泌。已建立哺乳的母亲体内的催乳素水平可能不会影响她母乳喂养的能力。低剂量眼科用药依匹斯汀不太可能对血清催乳素产生同样的影响。
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Research chemical 98% 50mg

Research chemical 98% 50mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:S80957-50mg
Product model:50mg
level: 98% 50mg
Lead Time:30days
sold 352 Items
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