Share to
Overview
Specs
Technical Documents
Related
Articles
reviews
Consult
returns
Product introduction
AZ960是高效选择性的JAK2激酶抑制剂,Ki值为0.45 nM。 应用: AZ 960 是一种新型的,ATP竞争性的JAK2抑制剂,IC50和Ki分别低于3 nM和0.45 nM,作用于JAK2比作用于JAK3选择性高3倍。AZ 960 可诱导凋亡和生长阻滞。对其它JAKs家族成员,例如 JAK1、JAK3和TYK2以及其它激酶,包括TrkA、Aurora A和FAK的抑制作用较小,IC50大约为0.1 μmol/L。最近的研究表明AZ960对成人T细胞白血病(ATL),CD4+ T淋巴细胞侵略性恶性肿瘤具有一定的抗癌活性,主要是通过诱导人类T细胞嗜淋巴细胞病毒1型(HTLV-1)感染的T细胞的生长停滞和细胞凋亡发挥作用。
Chinese name
AZ 960, Janus 激酶 2 抑制剂
English name
AZ 960
Chinese alias
5-氟-2-[[(1S)-1-(4-氟苯基)乙基]氨基]-6-[(5-甲基-1H-吡唑-3-基)氨基]-3-吡啶腈,AZ-960,AZ960)
English alias
(S)-5-fluoro-2-((1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)nicotinonitrile | NCGC00346581-01 | AZ 960;AZ960 | (S)-5-Fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile | 3-(3-(((Dimethylamino)me
CAS number
905586-69-8
molecular formula
C18H16F2N6
molecular weight
354.36 g/mol
Exact mass
-
PSA
89.400 Ų
Logp
4.400
Technical Documents
「No technical documents」
Related
「No upstream and downstream information yet」
Articles
「No related articles yet」
user reviews
Loading...
Consultation

Warm reminder:

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.!

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ,We will handle it for you as soon as possible, thank you for your support and trust.!

MedMol AZ 960 98% 1mg

MedMol AZ 960 98% 1mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:S81086-1mg
Product model:1mg
level:
Lead Time:30days
sold 39 Items
Ask Solution engineer
Qty

Recommended for you