AHU-377是中性溶酶的抑制剂，IC50值为5 nM。AHU-377和血管紧张素II AT1受体拮抗剂缬沙坦以1：1的摩尔比组成LCZ696。LCZ696是一种血管紧张素受体中性溶酶抑制剂。它可以降低血压，可能是治疗心力衰竭的新药。AHU-377是一种前药，可以通过将乙酯进行酶解将其转化为活性形式LBQ657。据报道，AHU-377（30和100 mg / kg，PO）可以在Dahl-SS大鼠中以剂量依赖的方式引起降压作用。但是在DOCA盐高血压大鼠中，它显示出微弱的降低。 AHU-377 is an inhibitor of neprilysin with IC50 value of 5 nM. AHU-377 and the angiotensin II AT1 receptor antagonist valsartan compose LCZ696 in a 1:1 molar ratio. LCZ696 is an angiotensin receptor neprilysin inhibitor. It can reduce blood pressure and may be a novel drug for the treatment of heart failure. AHU-377 is a prodrug, it can be converted by enzymatic cleavage of the ethyl ester into the active form LBQ657. It is reported that AHU-377(30 and 100 mg/kg, PO) can cause antihypertensive effect in a dose-dependent manner in Dahl-SS rats. But in the DOCA-salt hypertensive rats, it shows a weak reduction.