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Product introduction
MMAD 是一种有效的微管 (tubulin) 抑制剂,是抗体药物偶联物 (ADCs) 中的活性分子。 MMAD属于阿里他汀(auristatin)类,阿里他汀常被用作抗体药物偶联物(ADC)中的药物。在ADCs中,治疗性化合物和高选择性抗体由连接子结合,通过MAbs的抗原选择性优势,它可以将这些细胞毒性药物传送到表达抗原的肿瘤细胞中,从而增加治疗的有效性和安全性。作为ADCs的有效载荷,MMAD用于靶向肿瘤细胞的微管蛋白,它可以干扰微管蛋白聚合,在低皮摩尔浓度时诱导快速的细胞死亡。 此外,据报道,MMAD用于位点特异性抗体药物偶联物(NDCs)的生产。在NDCs中,MMAD与抗5T4抗体或抗Her2抗体相结合。NDCs具有更好的疗效和药代动力学。 Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload and antibody drug conjugate.
Chinese name
单甲基澳瑞他汀 D(MMAD)
English name
MMAD
Chinese alias
单甲基澳瑞他汀 D
English alias
Monomethylauristatin D | Monomethyl Dolastatin 10 | Demethyldolastatin 10
CAS number
203849-91-6
molecular formula
C41H66N6O6S
molecular weight
771.06 g/mol
Exact mass
-
PSA
170.000 Ų
Logp
5.300
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MedMol MMAD 99% 100mg

MedMol MMAD 99% 100mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:S84312-100mg
Product model:100mg
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Lead Time:30days
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