- Treatment： 苯茚二酮中毒的主要解毒剂是立即给予维生素K1（最初缓慢静脉注射10-25 mg，每3-6小时重复一次，直到凝血酶原时间正常化；然后每天口服10 mg，四次作为"维持剂量"）。这是一种极其有效的解毒剂，前提是在受害者的循环系统受到过多损害之前发现中毒。高剂量的苯茚二酮可能对身体影响数月，解毒剂必须长期定期给予。(L1257)
- exposure pathway： 摄入(L1817)；经皮(L1817)。从胃肠道缓慢吸收。
- Toxicity summary： 苯茚二酮抑制维生素K还原酶，导致维生素K的还原形式(维生素KH2)耗竭。由于维生素K是维生素K依赖蛋白N端区域谷氨酸残基羧化的辅因子，这限制了γ-羧化和随后维生素K依赖性凝血蛋白的激活。维生素K依赖性凝血因子II、VII、IX和X以及抗凝蛋白C和S的合成受到抑制。四种维生素K依赖性凝血因子中的三种(因子II、VII和X)的减少导致凝血酶原水平降低，以及与纤维蛋白结合的凝血酶生成量减少。这降低了血栓的血栓形成性。(A308)
- Toxicity Data： 口服，小鼠：LD50 = 175 mg/kg；口服，大鼠：LD50 = 163 mg/kg。
- Health Effects： 苯茚二酮是一种抗凝剂，可能导致内出血，引起休克、意识丧失，最终导致死亡。(L1257)
- Symptoms and Signs： 苯茚二酮可能导致出血并发症。(L1257)
- Human toxicity extract： ...具有抗甲状腺作用&...损害肾小管对尿酸盐的重吸收&因此增加尿液中尿酸的量。
- Hazard categories and classifications： 皮肤致敏物 1 (95.3%)
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
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Research chemical ≥98% 50mg
Research chemical ≥98% 50mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.
