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Product introduction

(R)-CR8 (CR8) 是 Roscovitine 的第二代类似物，是一种有效的 CDK1/2/5/7/9 抑制剂。(R)-CR8 (CR8) 抑制 CDK1/cyclin B (IC50=0.09 μM)、CDK2/cyclin A (0.072 μM)、CDK2/cyclin E (0.041 μM)、CDK5/p25 (0.11 μM)、CDK7/cyclin H (1.1 μM)、CDK9/cyclin T (0.18 μM) 和 CK1δ/ε (0.4 μM)。(R)-CR8 (CR8) 诱导细胞凋亡并具有神经保护作用。(R)-CR8 作为一种分子胶降解剂来消耗细胞周期蛋白 K。（R）-CR8 (CR8), a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 induces apoptosis and has neuroprotective effect. (R)-CR8 acts as a molecular glue degrader that depletes cyclin K.

Specs ⸢ View details ⸥

Chinese name

(R)-CR8, 细胞周期蛋白依赖性激酶 1 抑制剂

English name

(R)-CR8

Chinese alias

English alias

EN300-25631346 | BDBM50154937 | NCGC00370890-01 | RC8 | HMS3229B13 | (2R)-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]butan-1-ol | CR8 | CR-8 | DB08463 | GTPL11065 | SCHEMBL13001902 | (R)-2-(9-Isopropyl-6-(4-(pyridin-2-yl)benzy

CAS number

294646-77-8

molecular formula

C24H29N7O

molecular weight

431.53 g/mol

Exact mass

PSA

101.000 Å²

Logp

3.800

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Research chemical 98% 5mg

Name: Research chemical 98% 5mg
Brand: MedMol
SKU: S87699-5mg

Research chemical 98% 5mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number：S87699-5mg

Product model：5mg

level： 98% 5mg

Lead Time：30days

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Research chemical 98% 5mg

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