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Product introduction
AZD7325是一种有效且具有活性的部分选择性正变构调节剂(PAM),作用于GABAAα2和Aα3受体,Ki分别为0.3 和1.3 nM,对Aα1和Aα5的拮抗作用较小。 应用: AZD7325 是具有活性的 α2,3 receptor 的正向别构调节剂 (PAM),Ki 分别是 0.3 and 1.3 nM,但在 α1 和 α5 受体亚型上效果较差。AZD7325 是一种中等 CYP1A2 和强效 CYP3A4 诱导剂。AZD7325 具有用于焦虑和 dravet 综合征相关研究的潜力。 Information AZD7325 is a positive allosteric modulator (PAM) of α2,3 subtype-selective GABA receptor with pKi of 9.51 and has less efficacy at the α1 and α5 receptor subtypes. AZD7325 is a moderate CYP1A2 and a potent CYP3A4 inducer in vitro.
Chinese name
AZD-7325, GABA A 受体 α2 亚基的变构调节剂
English name
AZD-7325
Chinese alias
-
English alias
AKOS037649295 | Q27074785 | SB17497 | D81581 | DB13994 | HY-111052 | KYDURMHFWXCKMW-UHFFFAOYSA-N | UNII-KNM216XOUH | MFCD21337369 | KNM216XOUH | AZD 7325 | AZD 7325; AZD7325 | 3-CINNOLINECARBOXAMIDE, 4-AMINO-8-(2-FLUORO-6-METHOXYPHENYL)-N-PROPYL- | GTPL77
CAS number
942437-37-8
molecular formula
C19H19FN4O2
molecular weight
354.38 g/mol
Exact mass
-
PSA
90.100 Ų
Logp
3.3
Technical Documents
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MedMol AZD7325 98% 100mg

MedMol AZD7325 98% 100mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:S87751-100mg
Product model:100mg
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Lead Time:30days
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