Product Describtion: LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility. Product Application： LY-294,002 hydrochloride has been used in the inhibition of: phosphoinositide 3-kinase (PI3K) in human lung cancer cell line autophagy in mesenchymal stem cells (MSCs). serine/threonine-specific protein kinase (AKT) signaling in fibroblasts and cardiac cells.