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Product introduction
KY-226 是一种有效的、口服活性的 protein tyrosine phosphatase 1B (PTP1B) 的选择性变构抑制剂,对人PTP1B的IC50值为0.28 μM。KY-226 通过增强 insulin 和 leptin 信号传导来发挥抗糖尿病和抗肥胖的作用。IC50 为 0.25 μM,且不激活 PPARγ 。KY-226 还可以保护神经元免受脑缺血损伤。 Information KY-226 KY-226 is a potent, selective, orally active and allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 μM for human PTP1B activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively. Targets PTP1B (Cell-free assay) 0.28 μM
Chinese name
KY-226
English name
KY-226
Chinese alias
-
English alias
Benzamide,4-​[[([1,​1'-​biphenyl]​-​4-​ylmethyl)​thio]​methyl]​-​N-​(hexylsulfonyl)​-
CAS number
1621673-53-7
molecular formula
C27H31NO3S2
molecular weight
481.67 g/mol
Exact mass
10mM in DMSO
PSA
96.900 Ų
Logp
6.504
Technical Documents
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Research chemical 98% 1mg

Research chemical 98% 1mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:S88446-1mg
Product model:1mg
level: 98% 1mg
Lead Time:30days
sold 113 Items
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