Information OSS_128167 (SIRT6-IN-1) is a specificSIRT6inhibitor withIC50values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication. Targets SIRT6 (Cell-free); SIRT2 (Cell-free); SIRT1 (Cell-free) 89 μM; 751 μM; 1578 μM In vitro OSS-128167 is a selective compounds toward SIRT6 with IC50 values toward SIRT1 and SIRT2 being approximately 20 times higher. It is cell permeable and active in cultured cells. OSS-128167 increases H3K9 acetylation and GLUT-1 expression. Cell Research(from reference) Cell lines：BxPC3 cells Concentrations：100 μM Incubation Time：0, 2, 6, 18, 24 h