RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB 1 ) receptor with a pIC 50 of 7.54 in Ca 2+ mobilization assay. RTICBM-189 has pIC 50 s of 5.29 and 6.25 for hCB 1 and mCB 1 , respectively. RTICBM-189 significantly and selectively attenuates the reinstatement of the addictive agent-seeking behavior in rats In Vivo RTICBM-189 (10 mg/kg; i.p.) rapidly absorbs into systemic circulation, with peak plasma concentration (C max,plasma =288.4 ng/mL) observed at t max,plasma of 0.4 h post-dose. Peak brain levels are also reached at t max,brain of 0.4 h with a significantly higher C max,brain value of 594.6 ng/mL in the brain . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult male Sprague-Dawley rats weighing 280-300 g Dosage: 10 mg/kg Administration: IP Result: Significantly attenuated drug-induced reinstatement of the cocaine-seeking behavior. Animal Model: Male Sprague-Dawley rats weighing 258-277 g Dosage: 10 mg/kg (Pharmacokinetic Analysis) Administration: IP Result: Plasma: C max (288.4 ng/mL), t max (0.4 hours), CL_F (240.6 mL/min/kg), AUC inf (715.2 ng/mL × h), half-life t 1/2 (9.9 hours).\nBrain: C max (594.6 ng/mL), t max (0.4 hours), CL_F (120.7 mL/min/kg), AUC inf (1438.2 ng/mL × h). Form:Solid IC50& Target:CB1 7.54 (pIC 50 ) hCB 1 5.29 (pIC 50 ) mCB 1 6.25 (pIC 50 )