说明： UPGL00004是一种有效的谷氨酰胺酶C(GAC)抑制剂(IC50=29nM;Kd=27nM)。UPGL00004强烈抑制高度侵袭性三阴性乳腺癌细胞系的增殖。 Information UPGL00004 UPGL00004 is a potent glutaminase C (GAC) inhibitor with an IC50 of 29 nM, showing high selectivity for GAC over GLS2. Targets glutaminase C (Cell-free assay) 29 nM In vitro UPGL00004 potently inhibits the growth of triple negative breast cancer cells, as well as tumor growth when combined with the anti-VEGF antibody bevacizumab. In vivo UPGL00004 potently suppresses tumor growth in a patient-derived xenograft model for breast cancer, when combined with the anti-angiogenesis, anti-VEGF monoclonal antibody bevacizumab. Cell Research(from reference) Cell lines：Breast cancer cells Concentrations：0-10 μM Incubation Time：6 days