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Product introduction
PF-543 是一种新型Sphingosine kinase 1 (SphK1,SK1) (鞘氨醇激酶)抑制剂,Ki为3.6 nM。PF-543 可诱导细胞凋亡、坏死和自噬。 PF-543 hydrochloride (Sphingosine Kinase 1 Inhibitor II hydrochloride) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2. PF-543 hydrochloride is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy.
Chinese name
PF 543 盐酸盐
English name
PF 543 hydrochloride
Chinese alias
(2R)-1-[[4-[[3-甲基-5-[(苯磺酰基)甲基]苯氧基]甲基]苯基]甲基] -2-吡咯烷甲醇盐酸盐
English alias
(2R)-1-[[4-[[3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2- pyrrolidinemethanol hydrochloride
CAS number
1706522-79-3
molecular formula
C27H31NO4S•HCl
molecular weight
502.07 g/mol
Exact mass
≥98%(HPLC)
PSA
75.200 Ų
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Research chemical 98% 5mg

Research chemical 98% 5mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:S89988-5mg
Product model:5mg
level: 98% 5mg
Lead Time:30days
sold 402 Items
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