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Product introduction

Takinib belongs to the aminobenzimidazole class of inhibitors. Takinib (EDHS-206) 是一种有效且选择性的 TAK1 抑制剂 (IC50=9.5 nM)，比 IRAK4 (IC50=120 nM) 和 IRAK1 (IC50=390 nM) 作用强 1.5 log 倍。Takinib 是一种TAK1自磷酸化的抑制剂，在 ATP 结合口袋内非竞争性结合。在类风湿关节炎和转移性乳腺癌细胞模型中，Takinib 诱导 TNF-α 刺激的细胞凋亡 (apoptosis)。Takinib 也是恶性疟原虫蛋白激酶 9 (PfPK9) 的抑制剂 (KD(app) of 0.46 nM)。 Application Takinib has been used as an inhibitor of transforming 28 growth factor - β-activated kinase -1 (TAK-1) in human leukemia monocytic THP-1 cells. It may be used as a TAK1 inhibitor in Jurkat cells.

Specs ⸢ View details ⸥

Chinese name

Takinib,TAK1/MAP3K7激酶抑制剂, CDC 类激酶 2 抑制剂

English name

Takinib

Chinese alias

English alias

N17080 | SCHEMBL20063046 | F0918-1884 | A928060 | Tox21_300612 | Diethyl phthalate, 99% | NSC789624 | NSC-789624 | UNII-Z56NTB3YHJ | CCG-267729 | Z332866662 | 1-N-(1-propyl-1H-1,3-benzodiazol-2-yl)benzene-1,3-dicarboxamide | AKOS037515558 | GTPL9655 | MFC

CAS number

1111556-37-6

molecular formula

C18H18N4O2

molecular weight

322.37 g/mol

Exact mass

PSA

90.000 Å²

Logp

2.300

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Research chemical 100mg; ≥98%; HPLC

Name: Research chemical 100mg; ≥98%; HPLC
Brand: 阿拉丁
SKU: T288176-100mg

Research chemical 100mg; ≥98%; HPLC; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 100mg; ≥98%; HPLC.

item number：T288176-100mg

Product model：100mg

level： 100mg; ≥98%; HPLC

Lead Time：30days

sold 628 Items

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100mg

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Research chemical 100mg; ≥98%; HPLC

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