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名称

代谢酶/蛋白酶

分子类型

小分子

英文别名

英文名称

Tazarotenic acid

货号

T302268-100mg

包装规格

100mg

浓度

≥98%(HPLC)

储存温度

2-8°C储存

运输条件

冰袋运输

产品介绍

white to light brown powder Biochemical/Physiological Effects： Tazarotene is transformed to tazarotenic acid with the help of esterases. Tazarotenic acid regulates the pathogenic aspects of psoriasis through normalizing abnormal keratinocyte differentiation. It possesses strong anti-hyperproliferative effects in skin and reduces inflammation. Tazarotenic acid, an active metabolite of tazarotene, is a potent and selective agonist of the retinoid receptor (RAR) that binds to RARα, RARβ, and RARγ. Tazarotenic acid relatively selective activates RARβ and RARγ. Tazarotenic acid is a first xenobiotic substrate of human retinoic acid hydroxylase CYP26A1 and CYP26B1.

CAS号

118292-41-4

分子式

C19H17NO2S

分子量

323.41 g/mol

MDL号

MFCD00872121

PubChem编号

147525

Isomeric SMILES

CC1(CCSC2=C1C=C(C=C2)C#CC3=NC=C(C=C3)C(=O)O)C

IIUPAC Name

6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylic acid

INCHI

1S/C19H17NO2S/c1-19(2)9-10-23-17-8-4-13(11-16(17)19)3-6-15-7-5-14(12-20-15)18(21)22/h4-5,7-8,11-12H,9-10H2,1-2H3,(H,21,22)

InChi Key

IQIBKLWBVJPOQO-UHFFFAOYSA-N

Smiles

CC1(CCSC2=C1C=C(C=C2)C#CC3=NC=C(C=C3)C(=O)O)C

PubChem CID

147525

PubChem SID

504757309

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

323.098 Da

单同位素质量Monoisotopic Mass

323.098 Da

拓扑极表面积Topological Polar Surface Area

75.500 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

518.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

4.200

RIDADR

NONHforallmodesoftransport

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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Research chemical 100mg; ≥98%; HPLC

Name: Research chemical 100mg; ≥98%; HPLC
Brand: 阿拉丁
SKU: T302268-100mg

Research chemical 100mg; ≥98%; HPLC; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 100mg; ≥98%; HPLC.

item number：T302268-100mg

Product model：100mg

level： 100mg; ≥98%; HPLC

Lead Time：30days

sold 332 Items

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Specifications：

100mg

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Research chemical 100mg; ≥98%; HPLC

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