- Treatment： 砷中毒可以通过螯合疗法治疗，使用二巯基丙醇、EDTA或DMSA等螯合剂。对于不太严重的病例，也可使用炭片。此外，保持高硫饮食有助于从体内排出砷。(L20)
- exposure pathway： 口服(L2)；吸入(L2)；经皮(L2)
- Toxicity summary： 砷及其代谢物通过多种机制破坏ATP产生。在三羧酸循环水平，砷抑制丙酮酸脱氢酶，并通过与磷酸竞争解偶联氧化磷酸化，从而抑制能量相关的NAD+还原、线粒体呼吸和ATP合成。过氧化氢的产生也增加，这可能形成活性氧物种和氧化应激。砷的致癌性受砷化合物与微管结合的影响，这导致非整倍体、多倍体和有丝分裂停滞。砷与其他蛋白质靶标的结合也可能导致DNA修复酶活性改变、DNA甲基化模式改变和细胞增殖。(T1, A17)
- Regulatory information： REACH限制物质：限制条件文件：PDF链接
- Health Effects： 砷中毒可导致多系统器官衰竭死亡，可能是由于坏死性细胞死亡而非细胞凋亡。砷也是已知的致癌物，特别是皮肤、肝脏、膀胱和肺癌。(T1, L20)
- Symptoms and Signs： 接触低水平的砷可引起恶心和呕吐，红细胞和白细胞生成减少，心律异常，血管损伤，以及一种
- Minimum Risk Level： 急性口服：0.005 mg/kg/day (L134) 慢性口服：0.0003 mg/kg/day (L134) 慢性吸入：0.01 mg/m3 (L134)
- Other safety information： 化学品评估：IMAP评估 - [3-(乙酰氨基)-4-羟基苯基]砷酸：人类健康I级评估
- Hazard categories and classifications： 水生慢性1级（100%）
- Carcinogen Classification： 3，对人致癌性无法分类。(L135)
- Drug Induced Liver Injury： 参考文献：DOI:10.1016/j.drudis.2019.09.022
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Research chemical CAS 97-44-9 5g
Yuanye Research chemical CAS 97-44-9 5g, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.
