顺式ACCP 是IV型胶原特异性MMP-2和MMP-9的可逆竞争性抑制剂，优先于MMP-2（分别为IC | 50 | = 4和20μM）。在100μM浓度下，顺式ACCP可以在体外阻止90％的肿瘤细胞跨过基质胶包被的膜侵袭。基质金属蛋白酶（MMP）属于蛋白酶家族，通过降解细胞外基质蛋白，从而在组织修复和重塑中起关键作用，从而使细胞迁移。MMPs的过表达与诸如关节炎，癌症，骨质疏松和动脉硬化等疾病有关。 cis-ACCP is a reversible and competitive inhibitor of type IV collagen-specific MMP-2 and MMP-9 with preference towards MMP-2 (IC|50|= 4 and 20 μM, respectively). At 100 μM, cis-ACCP prevents 90% of tumor cell invasion across matrigel-coated membranes in vitro. Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue repair and remodeling by degrading extracellular matrix proteins, thus enabling cell migration. Overexpression of MMPs are linked to diseases such as arthritis, cancer, osteoporosis and arteriosclerosis.