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Product introduction

Product introduction A cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC50 = 0.25 µM in an oxidative stress model using cortical neurons.

Specs ⸢ View details ⸥

Chinese name

Adaptaquin,HIF-脯氨酰羟化酶2（PHD2）抑制剂

English name

Adaptaquin

Chinese alias

7-[(4-氯苯基)[(3-羟基-2-吡啶基)氨基]甲基] -8-喹啉醇

English alias

7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol

CAS number

385786-48-1

molecular formula

C21H16ClN3O2

molecular weight

377.82 g/mol

Exact mass

≥97%(HPLC)

PSA

78.300 Å²

Logp

4.500

Technical Documents

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Research chemical CAS 385786-48-1 98% 10mg

Name: Research chemical CAS 385786-48-1 98% 10mg
Brand: 源叶
SKU: T31018-10mg

Yuanye Research chemical CAS 385786-48-1 98% 10mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number：T31018-10mg

Product model：10mg

level： 98% 10mg

Lead Time：30days

sold 614 Items

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Research chemical CAS 385786-48-1 98% 10mg

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