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可逆的单胺氧化酶A抑制剂（MAOI）和抗抑郁药。属于一种相对新的可逆单胺氧化酶A抑制剂（MAOI）芳基恶唑烷酮。研究表明，通常用于治疗革兰氏阳性感染的衍生物（例如3-芳基恶唑烷-2-酮（恶唑烷酮））代表了一类新的可逆和不可逆的MAO-A和MAO-B酶抑制剂。抑制蛋白质合成，也用于神经退行性疾病。 A reversible monoamine oxidase A inhibitor (MAOI) and antidepressant. Belongs to the aryloxazolidinones, a relatively new class of reversible monoamine oxidase A inhibitors (MAOI). Studies show that derivatives such as 3-aryloxazolidin-2-one (oxazolidinones), which are regularly used to treat gram positive infections, represent a new class of reversible as well as irreversible inhibitors for MAO-A and MAO-B enzymes that are able to inhibit protein synthesis and also used for neurodegenerative-type pathologies.

Specs ⸢ View details ⸥

Chinese name

托洛沙酮, 单胺氧化酶 A 抑制剂

English name

Toloxatone

Chinese alias

English alias

(+/-)-5-(HYDROXYMETHYL)-3-M-TOLYL-2-OXAZOLIDINONE | 2-oxazolidinone, 5-(hydroxymethyl)-3-(3-methylphenyl)- | TOLOXATONE [MI] | 5-(Hydroxymethyl)-3-m-tolyl-2-oxazolidinone | 5-Hydroxymethyl-3-(m-tolyl)-2-oxazolidinone | D02559 | S0160 | FT-0630548 | HY-141

CAS number

29218-27-7

molecular formula

C11H13NO3

molecular weight

207.23 g/mol

Exact mass

10mM in DMSO

PSA

49.800 Å²

Logp

1.2

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