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类似Toll的受体7配体II是一种细胞可渗透的羟基腺嘌呤化合物，可作为强效且高度特异性的Toll样受体7（TLR7）激动剂，对TLR2 / 3/5/8/9没有任何可检测的活性。在刺激体外培养物中TLR7依赖性细胞因子的产生方面，其效力比R848高10倍。SM-360320 是一种免疫调节剂，具有抗肿瘤作用。SM-360320 可与 DNA 疫苗协同作用，从而增强 Th1 抗体反应。 Toll-Like Receptor 7 Ligand II is a cell-permeable hydroxyadenine compound which acts as a potent and highly specific toll-like receptor 7 (TLR7) agonist, without any detectable activity towards TLR2/3/5/8/9. It is shown to be 10-times more potent than R848 in stimulating the production of TLR7-dependent cytokines in cultures|in vitro|.SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity.

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Chinese name

类似Toll的受体7配体II

English name

Toll-Like Receptor 7 Ligand II

Chinese alias

English alias

CAS number

226907-52-4

molecular formula

C15H17N5O3

molecular weight

315.33 g/mol

Exact mass

≥98%

PSA

103.000 Å²

Logp

0.700

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