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Product introduction
VX-680 (Tozasertib, MK-0457)是一种pan-Aurora抑制剂,对Aurora A作用最强,Kiapp为0.6 nM,而对Aurora B/Aurora C的作用稍弱,对Aurora A选择性比其他55种激酶强高100倍。A potent and selective pan-ARK inhibitor VX-680 (Tozasertib, MK-0457) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases A potent and selective pan-ARK inhibitor;Aurora Kinase抑制剂
Chinese name
陶扎色替, 丝氨酸/苏氨酸蛋白激酶 Aurora 抑制剂
English name
Tozasertib
Chinese alias
陶扎色替
English alias
VX-680 | MK-0457 | Cyclopropane carboxylic acid{4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2-ylsulphanyl]-phenyl}-amide | Cyclopropanecarboxamide, N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyri
CAS number
639089-54-6
molecular formula
C23H28N8OS
molecular weight
464.6 g/mol
Exact mass
-
PSA
127.000 Ų
Logp
3.4
Technical Documents
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Tozasertib (VX-680, MK-0457) 10mM in DMSO 1ml

Tozasertib (VX-680, MK-0457) 10mM in DMSO 1ml; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 1ml.

item number:T407973-1ml
Product model:1ml
level: 1ml
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