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名称

Trastuzumab (anti-HER2), erb-b2 受体酪氨酸激酶 2 抗体

分子类型

抗体

别名

英文别名

8-Aminoguanosine, >=98% (HPLC) | SHO2CA1BRO | Guanosine, 8-amino- | SCHEMBL483333 | 2,8-diamino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-purin-6-one | PD183255 | NSC 90390 | NSC816045 | NSC-816045 | NSC-90390 | BDBM50227263

物理外观

Liquid

货号

T411999-100μg

包装规格

100μg

级别

无动物源

浓度

≥95%(SDS-PAGE&SEC-HPLC)

纯度

>95%

储存温度

-80℃储存,避免反复冻融

运输条件

超低温冰袋运输

稳定性与储存

短期储存2-8℃（1-2周）；长期储存-80℃（24个月）；收货后建议分装，避免反复冻融。

储存缓冲液

10mM PBS, pH6.0.

防腐剂

生化机理

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

应用

ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)

来源

CHO supernatant

宿主种属

人(Human)

种属反应性

人(Human), 小鼠(Mouse) | 人(Human),小鼠(Mouse)

特异性

ERBB2/HER2/CD340

CAS编号和信息

180288-69-1

SDS-PAGE

26.0 kDa (Light Chain) & 50.6 kDa (Heavy Chain), under reducing conditions; 188.5 kDa, under non-reducing conditions.

偶联

Unconjugated

亚型

Human IgG1

克隆类型

重组抗体

轻链亚型

kappa

纯化方法

Protein A purified

抗体类型

Primary antibody

Reaxy-Rn

24725081

作用类型

抑制剂

作用机制

erb-b2 受体酪氨酸激酶 2 抗体

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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