Tenovin-6是Tenovin-1的水溶性类似物，可作为有效的SIRT1和SIRT2抑制剂以及p53激活剂。SIRT1和SIRT2是蛋白质脱乙酰基酶，属于NAD | + |依赖的III类组蛋白脱乙酰基酶。尽管沉默调节蛋白在人类中的功能尚不完全清楚，但在酵母中，它们已经显示出调节表观遗传基因表达的功能。研究表明，tenovin-6比tenovin-1增加p53的水平，并且对酵母的毒性更大。Tenovin-6也已显示出抑制SIRT3的作用。 Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 and SIRT2 inhibitor as well as p53 activator. SIRT1 and SIRT2 are protein-deacetylases that belong to the NAD|+|-dependent class III histone deacetylases. Although the function of sirtuins in humans is not entirely known, in yeast, they have been shown to regulate epigenetic gene expression. Studies show that tenovin-6 increases p53 levels more than tenovin-1 and is also more toxic to yeast. Tenovin-6 has also been shown to inhibit SIRT3.