Bufrolin，作为Cromoglycate（组胺释放抑制剂）的类似物，是一种高效的GPR35激动剂，能够促进β-arrestin-2与人GPR35a或大鼠GPR35之间的相互作用。此外，Bufrolin亦可作为抗过敏性肥大细胞稳定剂，有效抑制内化肽诱导的抗炎反应，并且在内化肽连接药剂的药物递送研究中，被作为抗炎剂使用。 Bufrolin, an analog of Cromoglycate (histamine release inhibitor) and a potent agonist of GPR35, enhances the interaction between β-arrestin-2 and both human GPR35a and rat GPR35. It stabilizes mast cells, exhibiting antiallergic properties, and inhibits anti-inflammatory responses triggered by internalization peptides. Furthermore, Bufrolin is researched for its anti-inflammatory properties in pharmaceutic applications associated with internalization peptides.