- Treatment： 治疗为对症治疗。旨在控制惊厥、昏迷和呼吸抑制。摄入后可进行洗胃，随后给予活性炭。(L146)
- exposure pathway： 口服(L281)；吸入(A105)
- Toxicity summary： 氯丹被认为不可逆地结合到DNA上，导致细胞死亡或改变细胞功能。它还通过拮抗雌激素相关受体影响转录。氯丹诱导肝细胞色素P-450，导致内质网体积大幅增加，从而引起肝细胞增大和肥大。研究还表明，氯丹能够结合并激活视黄酸受体，引起各种发育缺陷，并抑制肝组织和肾组织中的碱性磷酸酶。(L91, A52, A53, A68, A69)
- Toxicity Data： LD50：200 mg/kg（口服，大鼠）（T13）LD50：343 mg/kg（腹腔注射，大鼠）（T13）LD50：10 mg/kg（静脉注射，小鼠）（T14）LD50：780 mg/kg（经皮，大鼠）（T14）LC50：100 mg/m3持续4小时（吸入，猫）（T14）
- Health Effects： 氯丹是中枢神经系统兴奋剂，也可能损害消化系统和肝脏。大剂量已知可引起惊厥、呼吸衰竭和死亡。氯丹还已知对生殖和发育有不良影响。(L91)
- Symptoms and Signs： 摄入和吸入氯丹会导致头痛、易怒、混乱、虚弱、视力问题、呕吐、胃痉挛、腹泻和黄疸。(L91)
- Minimum Risk Level： 吸入：0.0002 mg/m3 (L134) 慢性吸入：0.00002 mg/m3 (L134) 急性口服：0.001 mg/kg/day (L134) 中间口服：0.0006 mg/kg/day (L134) 慢性口服：0.0006 mg/kg/day (L134)
- Other safety information： 化学品评估：IMAP评估 - 4,7-甲撑-1H-茚，1,2,4,5,6,7,8,8-八氯-2,3,3a,4,7,7a-六氢-：人类健康I级评估
- RAIS Toxicity Values： 口服斜率因子参考：IRIS当前值
- Hazard categories and classifications： 水生慢性1级（100%）
- Carcinogen Classification： 2B，可能对人类致癌。(L135)
- Hazard Quotient Level 3 or Cancer Risk Level 1E-04： 土壤中皮肤吸收的污染物比例：0.04
- Hazard Quotient Level 0.1 or Cancer Risk Level 1E-06： 土壤中皮肤吸收的污染物比例：0.04
- USGS Health-Based Screening Levels for Evaluating Water-Quality： 参考文献: Smith, C.D. and Nowell, L.H., 2024. 用于评估水质数据的基于健康的标准水平 (第 3 版)。DOI:10.5066/F71C1TWP
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Research chemical CAS 12789-03-6 ≥98. 5% 50mg
Research chemical CAS 12789-03-6 ≥98. 5% 50mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.
