3',4'-Dihydroxyflavonol (DiOHF) is an effective antioxidant, which reduces superoxide and improves nitric oxide ( NO ) function in diabetic rat mesenteric arteries. In Vitro 3',4'-Dihydroxyflavonol (DiOHF) acutely preserves nitric oxide (NO) activity in the presence of elevated reactive oxygen species (ROS). DiOHF improves NO activity in diabetes by reducing Nox2-dependent superoxide production and preventing eNOS uncoupling to improve endothelial function. 3',4'-Dihydroxyflavonol reduces vascular contraction through Ca ²⁺ desensitization in permeabilized third-order branches of rat mesenteric arteries. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid