Share to

Overview

Specs

Technical Documents

Articles

reviews

Consult

returns

Product introduction

Tapotoclax 是一种针对诱导性髓系白血病细胞分化蛋白 MCL-1 的高效抑制剂 (Ki=0.13 nM)，具备潜在的促凋亡和抗肿瘤活性。给药后，Tapotoclax 与 MCL-1 结合，从而抑制其功能。这一过程阻止了 MCL-1 与 Bcl-2 类蛋白 11 (BCL2L11；BIM) 的复合物形成，并进一步触发肿瘤细胞凋亡。 Tapotoclax is a potent inhibitor (Ki=0.13 nM) of the inducible myeloid leukemia cell differentiation protein MCL-1, with potential pro-apoptotic and anti-tumor activity. Upon administration, Tapotoclax binds to MCL-1, thereby inhibiting its function. This process prevents the formation of a complex between MCL-1 and Bcl-2-like protein 11 (BCL2L11; BIM) and further triggers apoptosis in tumor cells.

Specs ⸢ View details ⸥

Chinese name

Tapotoclax

English name

Tapotoclax

Chinese alias

他普托克拉

English alias

BCP25146 | AKOS040741103 | EX-A2666 | VF8 | AMG 176 [WHO-DD] | SR-05000001528-2 | AC-36265 | MCL-1 inhibitor AMG 176 | 97W7N9T08G | MS-30719 | (3'R,4S,6'R,7'S,8'E,11'S,12'R)-7-chloro-7'-methoxy-11',12'-dimethyl-13',13'-dioxospiro[2,3-dihydro-1H-naphthalen

CAS number

1883727-34-1

molecular formula

C33H41ClN2O5S

molecular weight

613.21 g/mol

Exact mass

PSA

93.300 Å²

Logp

6.800

Technical Documents

「No technical documents」

「No upstream and downstream information yet」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！