Share to

Details

Safety

Technical Documents

Articles

reviews

Consult

returns

Product details

名称

TRULI

英文名称

TRULI

货号

T647262-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

TRULI (Lats-IN-1) is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. TRULI promotes Yap-dependent proliferation in postmitotic mammalian tissues. In Vitro The IC 50 for TRULI increases with the ATP concentration. TRULI (10 μM; 24 hours) interferes with the ability of Lats kinases to phosphorylate Yap, with an EC 50 of 510 nM. TRULI causes Yap-dependent proliferation of murine supporting cells in the inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids. TRULI fosters both the G1-S and G2-M checkpoint transitions and yields supporting cells capable of transdifferentiation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: MCF 10A cells Concentration: 10 μM Incubation Time: 24 hours Result: Decreased the phosphorylation of Yap at residue S127. Form:Solid

生化机理

TRULI（Lats-IN-1）是一种强效的 Lats1 和 Lats2 激酶 ATP 竞争性抑制剂。TRULI 能促进有丝分裂后哺乳动物组织中依赖 Yap 的增殖。

CAS号

1424635-83-5

分子式

C18H14N4OS

分子量

334.4 g/mol

PubChem编号

71890885

Isomeric SMILES

C1=CC=C(C=C1)CN2C=CSC2=NC(=O)C3=CNC4=C3C=CC=N4

IIUPAC Name

N-(3-benzyl-1,3-thiazol-2-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide

INCHI

1S/C18H14N4OS/c23-17(15-11-20-16-14(15)7-4-8-19-16)21-18-22(9-10-24-18)12-13-5-2-1-3-6-13/h1-11H,12H2,(H,19,20)

InChi Key

VTXBMVZVPUSAJF-UHFFFAOYSA-N

Smiles

C1=CC=C(C=C1)CN2C=CSC2=NC(=O)C3=CNC4=C3C=CC=N4

PubChem CID

71890885

溶解性

DMSO : 50 mg/mL (149.53 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

334.089 Da

单同位素质量Monoisotopic Mass

334.089 Da

拓扑极表面积Topological Polar Surface Area

86.700 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

529.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.000

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！